Journal Club - Role of CT Honeycombing in ILD progression


Calgary, Alberta


May 24, 2019

Discussion topic and resource: The role of Computed Tomography Honeycombing in Profiling Disease Progression in Chronic interstitial Lung Disease.

Reference:  Evans R. Fernandez Perez, M.D., M.S. Division of Pulmonary, Critical care and Sleep Medicine, National Jewish Health, Denver, Colorado.
AnnalsATS Volume 16 Number 5 pgs 580- 588 Published May 2019

Lead by:  Dr. O. Tourin
Duration: 45 minutes
Discussion: This study was focused on determining the prevalence and prognostic value of CT honeycombing and characterize associated mortality patterns across diverse ILD subtypes in a multicenter cohort.
Among those with CT honeycombing, cumulative mortality hazards were similar across ILD subtypes, except for CTD-ILD, which had lower mortality hazard. Overall, the mean survival time was shorter among those with CT honey-combing than those without CT honeycombing .

Conclusion:  CT honeycombing is prevalent in diverse forms of ILD and identifies a progressive fibrotic phenotype that is associated with increased mortality rates. Although CT honeycombing did not confer additional risk in IPF, other major ILD subtypes with the phenotype had higher mortality. This defining characteristic deserves further study to elucidate the common pathobiological mechanisms contributing to disease progression in subjects with CT honeycombing . Overall, the early recognition of the PF-ILD phenotype is of critical importance during the evaluation of persons with fibrotic lung disease, as this may improve the clinical decision-making process.

-Audrey, Rep (ROCHE); Olga Tourin, MD; Tammy Glas, RRT; Andrew Li, RRT; Stephanie Dick LPN,  

Dr. Olga Tourin